Santiago de Cuba Sesinye sezixeko onokundwendwela eCuba, ukongeza kwikomkhulu, iTrinidad entle, iCienfuegos okanye iPianr del Río, ukubiza nje ezo zithi qatha engqondweni ngoku. Ineembombo ezininzi zembali kunye nendawo elungileyo yokuqalisa ukhenketho Indlu kaDon Diego Velázquez.
UDiego Velázquez de Cuéllar wayengumoyisi oqhubela phambili waseSpain owaba yirhuluneli yokuqala yaseCuba ngo-1511. Wazalelwa kusapho oluhloniphekileyo lwaseCuéllar, waba lijoni kwaye kunyaka nje emva kokuba uColumbus efikile eMelika wawela iAtlantic waya kumazwe angaziwayo. Ufike kuhambo lwesibini lukaColumbus kwaye wazinikezela ekoyiseni nasekuphumeni eCuba kwaye ukusuka apha waxhasa uhambo olwaphela eMexico kwiminyaka kamva. E-Cuba wayehlala kwindlu enkulu ese-Santiago de Cuba kwaye kwigumbi lakhe lokulala kule ndlu wasweleka ngobusuku buka-Juni 11 ukuya ku-12, 1524. Le ndlu yakhiwa phakathi ko-1516 no-1530. Yeyona ndlu indala kunazo zonke ilizwe.
Inezinto zobugcisa beMudejar, iibhalkhoni, iilethi, udonga lwamatye, igolide nesilivere yokunyibilikisa iziko kunye neengcango ezininzi zokuqala, iifestile nophahla. Ubuncwane bokwenene. Ikwanayo nepatio esembindini enequla. Ungaphuthelwa kuba namhlanje iyasebenza ngaphakathi kweMyuziyam yezeNdalo ngeMbali.