Santiago de Cuba Ngenye yamadolobha ongavakashela kuwo eCuba, ngaphezu kwenhlokodolobha, iTrinidad enhle, iCienfuegos noma iPIanr del Río, ukubiza nje lawo afika engqondweni manje. Inamakhona amaningi omlando futhi indawo enhle yokuqala ukuvakasha yi- Indlu kaDon Diego Velázquez.
UDiego Velázquez de Cuéllar wayengumnqobi othuthukile waseSpain owaba ngumbusi wokuqala waseCuba ngo-1511. Wazalelwa emndenini ohloniphekile waseCuéllar, waba yisosha futhi ngemuva konyaka nje uColumbus efikile eMelika wawela i-Atlantic waya emazweni angamboziwe. Wafika ohambweni lwesibili lukaColumbus futhi wazinikela ekunqobeni nasekugcwaliseni iCuba, futhi esuka lapha waxhasa imikhankaso eyaphela eMexico eminyakeni eyalandela. ECuba ubehlala endlini enkulu eseSantiago de Cuba kanti egumbini lakhe lokulala kule ndlu ushone ngobusuku bukaJuni 11 kuya ku-12, 1524. Le ndlu yakhiwa phakathi kuka-1516 no-1530 futhi yindlu endala kunazo zonke we bafowethu.
Inezinto zobuciko beMudejar, ama-balcony, ama-lattices, izindonga zamatshe, isithando somlilo sokuncibilikisa segolide nesiliva neminyango eminingi yasekuqaleni, amawindi nophahla. Kuyigugu langempela. Iphinde ibe nepatio emaphakathi enethangi. Ungaphuthelwa ngoba namuhla isebenza ngaphakathi kweMnyuziyamu Yezemvelo.